Comparison of effectiveness of three testosterone preparations in man and rats.

Abstract

SUBSTITUTIVE therapy of endocrine deficiencies attempts, as far as possible, to emulate the normal secretory activity of the gland in question. In the treatment of eunuchoidism this has been reasonably accomplished by injection of testosterone propionate in oil (1) or of testosterone in aqueous suspension (2). Both these preparations have a rather protracted activity and therefore the need for multiple injections is reduced. Recently another testosterone preparation, testosterone β-cyclopentylpropionate (TCP), was made available to us for clinical trial and it was deemed advisable to compare its effects with those of the propionate and the aqueous suspension, in the therapy of male hypogonadism. Its androgenic activity was also tested in laboratory animals. METHODS AND RESULTS Urinary 17-ketosteroid excretion following testosterone propionate in oil and testosterone in aqueous suspension In the first part of this investigation, 7 patients with primary hypogonadism were given testosterone propionate in oil...