Clinical effect of propofol combined with butorphanol on endoscopic retrograde cholangiopancreatography

Abstract

Objective To investigate the effect of propofol combined with butorphanol on hemodynamics and anesthesia complications in patients with endoscopic retrograde cholangiopancreatography (ERCP), and to provide a reference for the selection of ERCP. Methods A total of 120 patients with ERCP were selected, aged 31-59 years, ASA grade Ⅰ-Ⅱ, BMI 17.9-25.4kg/m2, no general anesthesia contraindications before surgery, no opioid allergy history, no liver and kidney dysfunction.The patients were randomly divided into two groups with computer software: propofol + butorphanol group (B group) and propofol + remifentanil group (R group). The systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate (HR), oxygen saturation (SpO2) were recorded at the time of anesthesia induction (T0), immediately after injection of propofol (T1), 10 min (T2) after propofol injection, before ending (T3) and immediate after recovery (T4). At the same time, the propofol induced dose, propofol maintenance dose and awakening time were recorded.Regarding the adverse reactions, the intraoperative hypotension, PONV, lethargy, intraoperative physical movement, skin itching were recorded. Results The levels of SBP in R group were significantly lower than those in B group at T1, T2, T3 and T4 (t=3.952, 4.876, 5.190, 4.391, all P 0.05). The incidence rates of hypotension and hypoxia in B group were significantly lower than those in R group (14 cases vs.5 cases, 10 cases vs.3 cases, χ2=5.065, 4.227, all P<0.05). Conclusion Butorphanol can provide good analgesic effect to patients undergoing ERCP, while maintaining hemodynamics stability, the patients' respiratory depression is also mild and does not increase the incidence of other anesthesia-related complications risk, with good effect and safety.It is worth to promote in clinical. Key words: Butorphanol; Remifentanil; Cholangiopancreatography, endoscopic retrograde; Hemodynamics