Abstract
Objective To investigate the clinical effect of monosialotetrahexosyl ganglioside in the treatment of neonatal intracranial hemorrhage. Methods From January 2016 to December 2018, 142 neonates with intracranial hemorrhage admitted to the Maternal and Child Health Hospital of Zhoushan were randomly divided into observation group (71 cases) and control group (71 cases) according to the digital table.The control group was treated with routine treatment, while the observation group was treated with ganglioside needle on the basis of the control group.Both two groups were treated for 14 days.The therapeutic effects, muscle tone recovery time, reflex recovery time and consciousness recovery time were compared.The changes of neurobehavioral assessment score (NABA score), TNF-α, IL-1β, MMP-2, TIMP-1 and NSE levels before and after treatment were compared. Results The total effective rate of the observation group (92.96%) was higher than that of the control group (77.47%) (χ2=6.762, P<0.05). The recovery time of muscle tension, reflex and consciousness in the observation group [(7.68±1.29)d, (6.83±1.20)d and (8.34±1.54)d] were shorter than those in the control group [(10.25±2.31)d, (9.17±1.86)d and (10.53±1.08)d] (t=8.185, 8.908, 9.811, all P<0.05). After treatment, the NABA score of the observation group[(40.37±0.65)points] was higher than that of the control group[(37.16±0.93)points](t=23.838, P<0.05). The serum levels of TNF-α [(26.37±4.25)pg/L], IL-1β [(16.74±3.24)ng/L], MMP-2 [(78.39±16.57)g/L], TIMP-1 [(179.32±17.65)ng/mL] and NSE [(13.52±2.19)g/L] in the observation group were lower than those in the control group [(53.21±7.39)pg/L, (28.93±5.64)ng/L, (97.42±12.63)g/L, (238.63±28)ng/mL and (21.43±2.89)μg/L] (t=26.529, 15.792, 7.696, 14.938, 18.381, all P<0.05). Conclusion Ganglioside has good therapeutic effect on neonatal intracranial hemorrhage.It can reduce the serum levels of TNF-α, IL-1β, MMP-2, TIMP-1 and NSE, and improve the neurobehavioral function of neonates. Key words: Intracranial hemorrhages; Tumor necrosis factor-alpha; Interleukin-1beta; Matrix Metalloproteinase 2; Monosialotetrahexosyl ganglioside; Infant, newborn
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