Clinical effect of mifepristone combined with misoprostol for termination of pregnancy in high risk pregnant women

Abstract

Objective To explore the clinical effect of mifepristone combined with misoprostol for termination of pregnancy in high risk pregnant women and provide reference for clinical treatment. Methods 182 cases of high-risk maternal were divided into observation group and control group by the random number table method, each group 91 cases.The control group was treated with conventional abortion termination of pregnancy, the observation group was treated with the artificial abortion before oral administration of mifepristone tablets and misoprostol tablets.The operation time, the amount of blood loss, the degree of pain, the degree of cervical softening and the occurrence of complications of induced abortion were compared between the two groups. Results The operation time of the observation group was (2.21±1.41)min, intraoperative bleeding was (15.29 ±4.06)mL, which were significantly less than those of the control group (t=7.122, 8.256, all P<0.05); The pain degree grade I in the observation group was 58.24%, which was significantly higher than that in the control group, grade III accounted for 5.49%, which was significantly lower than the that in the control group (χ2=44.887, 44.121, all P<0.05), the observation group of cervical softening full was 59 cases, full softening rate was 64.84% and the control group in the cervical softening full was 41 cases, softening full rate was 45.05%.Fully softening rate in the observation group was significantly higher than that in the control group (χ2=7.191, 8.411, P<0.05), the control group, the incidence of uterine perforation in 2 cases, the occurrence of artificial abortion syndrome 7 cases, the incidence of complications for 9.89%, the observation group had no uterine perforation occurred, 1 case of artificial abortion syndrome and complications occurred rate was 1.10%.The incidence of complications in the observation group was significantly lower than that in the control group (χ2=6.772, P<0.05). Conclusion Mifepristone combined with misoprostol for high-risk maternal termination of pregnancy could significantly shorten the artificial abortion operation time, reduce intraoperative blood loss, reduce the patient pain, reduce the incidence of complications. Key words: High risk maternal; Termination of pregnancy; Mifepristone; Misoprostol