Clinical effect of mifepristone combined with card progesterone plugs and misoprostol tablets in vaginal preparation before curettage in large months

Abstract

Objective To compare the clinical effects of mifepristone combined with card progesterone plugs and misoprostol tablets on vaginal preparation before forcep curettage in large months (10-14 weeks gestation). Methods A total of 90 cases of pregnant women treated in Changzhi Maternal and Child Health Hospital from June 2015 to June 2017 who were 10 to 14 weeks pregnant and required termination of pregnancy were selected. All the women were divided into control group and observation group according to random number table method, with 45 cases in each group. Patients in the two groups were given mifepristone (25 mg/tablet) orally, one tablet in the morning and one tablet in the evening, for three consecutive days. Patients in control group were given card progesterone plugs, while patients in observation group were given misoprostol. The ervical dilation, cervix softening time, vaginal bleeding amount, delivery times, drug cost and incidence of adverse reactions of the two groups were compared. Results There was no significant difference in cervical dilatation, cervical softening time or vaginal bleeding between the two groups (P>0.05). Compared with control group, observation group had fewer requirement of administration and lower cost of administration, and the difference was statistically significant (P 0.05). Conclusions Misoprostol combined with mifepristone can achieve good curative effect in the preoperative preparation of forceps scraping in large months. Key words: Mifepristone; Misoprostol; Card progesterone plugs; Vaginal administration; Forcep curettage