Abstract
Objective To investigate the clinical effect of ibuprofen on preventing intracranial hemorrhage in premature infants and its influence on the levels of NT-proBNP and ET-1. Methods From January 2016 to December 2017, 112 premature infants in Taizhou Hospital were selected as study objects after screening by inclusion and exclusion criteria.The infants were randomly divided into observation group and control group according to the digital table, with 56 cases in each group.The control group was treated with routine therapy, and the observation group was given ibuprofen prophylaxis.The incidence of intracranial hemorrhage, clinical index and serum NT-proBNP, ET-1 levels were compared between the two groups. Results There was significant difference in the incidence rate of intracranial hemorrhage between the observation group (17.86%) and the control group (30.36%)(χ2=12.472, P 0.05). There were no statistically significant differences in feeding intolerance and gastric hemorrhage between the two groups(all P>0.05). Conclusion The application of ibuprofen suspension can effectively prevent intracranial hemorrhage in premature infants, which is worthy of clinical use. Key words: Premature; Intracranial hemorrhage; Ibuprofen; NT-proBNP; ET-1
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