Clinical effect of head hypothermia combined with mouse nerve growth factor in the treatment of neonatal moderately severe hypoxic ischemic encephalopathy

Abstract

Objective To observe the curative effect of head hypothermia combined with mouse nerve growth factor in the treatment of neonatal moderately severe hypoxic ischemic encephalopathy (HIE). Methods 50 cases of severe HIE were randomly divided into observation group and control group, with 25 cases in each group.Both two groups were given the conventional treatment.The observation group was given head hypothermia treatment in 6 hours after born, to maintain the nasopharyngeal temperature (34.0±0.5)℃, anal temperature (35.5±0.5)℃, 72 hours continuously.At 96 hours after the birth, the nerve growth factor was given.The control group did not give the head mild hypothermia treatment.At 96 hours after birth, the nerve growth factor (methods, dosage and treatment were the same as the observation group) was treated with nutrition and brain nerve.After treatment, the improvements of heart rate, muscle tension, convulsions and disturbance of consciousness were observed in two groups.After 3 days, 2 weeks and 4 weeks, the neonatal behavioral neurological assay (NBNA), 1 and 3 months after birth, the outfit cranial MRI plain scan and brainstem auditory evoked potential (BAEP) were evaluated. Results NBNA scores of the two groups were compared in 3 days, 2 weeks and 4 weeks after birth, the differences were statistically significant (t=2.53, 2.89, 3.23, all P<0.05). In the observation group, the abnormal brain MRI was significantly less than the control group, the difference was statistically significant (χ2=24.125, P<0.05). In the observation group, the number of abnormal auditory evoked potential was significantly less than that of the control group, the difference was statistically significant (χ2=21.312, P<0.01). Conclusion Head hypothermia combined with mouse nerve growth factor therapy for the treatment of neonatal moderately severe HIE has protective effect, it can improve the treatment efficacy, reduce the long-term neurological sequelae, and without adverse reaction. Key words: Hypoxic ischemic, brain; The head hypothermia; Mouse nerve growth factor