Effect of mouse nerve growth factor on dysphagia in patients with esophageal cancer after radiation therapy

Abstract

Objective To investigate the effect of mouse nerve growth factor on esophageal dysphagia patients after radiation therapy. Methods From July 2012 to March 2016, 114 esophageal cancer patients after radiotherapy with dysphagia were selected, based on the random number table method, they were divided into observation group (mouse nerve growth factor and routine therapy) and control group (conventional treatment). The clinical efficacy and swallowing function were compared between the two groups. Results There were 57 cases in observation group, markedly effective in 22 cases (38.60%), effective in 25 cases (43.86%), invalid in 10 cases (17.54%), the total effective rate was 82.46%; in the control group (57 cases), markedly effective in 8 cases (14.04%), effective in 19 cases (33.33%), invalid in 21 cases (36.84%), deterioration in 9 cases (15.79%), the total effective rate was 47.37%, the difference of the total effective rate between the two groups was significant (P 0.05). After treatment, the pharyngeal start delay time, the number of invalid swallowing were significantly lower than those in the control group, throat range of motion was significantly higher, the differences were significant (P 0.05). After treatment, the water drinking test grade Kubota in observation group was significantly lower than that in the control group, FOIS score and VFSS score were significantly higher, the differences were significant (P<0.05). Conclusions Mouse nerve growth factor can significantly improve esophageal row after radiation therapy in patients with dysphagia swallowing function of patients, to repair damaged nerve is important. Key words: Mouse nerve growth factor; Esophageal cancer; Radiotherapy; Difficulty swallowing