Clinical effect and influence of sequential therapy on serum levels of IL-10 and TNF-α in children with peptic ulcer

Abstract

Objective To explore the clinical efficacy, adverse reactions and serum levels of IL-10 and TNF-α in children with peptic ulcer undergoing sequential therapy. Methods 68 children with peptic ulcer were selected and randomly divided into two groups, 34 cases in each group.The control group received quadruple therapy, namely omeprazole, amoxicillin, clarithromycin and bismuch treatment for seven days.The treatment group underwent sequential therapy: the first 5 d of oral omeprazole, amoxicillin treatment, and the next 5 d omeprazole, amoxicillin and inidazole treatment.The clinical efficacy, adverse reactions, IL-10 and TNF-α levels of the two groups were compared. Results The total effective rates after treatment of the control group and treatment group were 88.24% and 91.18% respectively, there was no statistically significant difference between the two groups(χ2=1.21, P>0.05). After treatment, the levels of IL-10 and TNF-α in the control group were (24.93±6.29)pg/mL and (37.93±8.28)pg/mL, which were significantly decreased (t=5.52, P<0.05, t=8.51, P<0.01). And the levels of IL-10 and TNF-α in the treatment group were (21.36±6.31)pg/mL and (29.67±6.38)pg/mL, which were significantly decreased(t=11.15, 12.29, all P<0.01). The levels of IL-10 and TNF-α of the treatment group were much significant than those of the control group after the sequential therapy (t=3.32, P<0.05, t=8.71, P<0.01). Conclusion Sequential therapy for the treatment of children with peptic ulcer has better effect than the quadruple therapy, and can reduce serum IL-10 and TNF-α levels, it is worthy of promoting. Key words: Peptic ulcer; Interleukin-10; Tumor necrosis factor-alpha; Child