Abstract
Objective To determine the characteristics and outcome of the severe preeclampsia patients concurrent HELLP syndrome admitted in intensive care unit(ICU). Methods Patients with severe preeclampsia admitted were identified and divided into the two groups according to with or without HELLP syndrome. The characteristics, organ function, treatment and outcome were compared between two groups. Results Of 61 severe preeclampsia patients,18 patients were diagnosed HELLP syndrome(18/61,29.51%). Compared with patients without HELLP syndrome, the age, rate of regular prenatal care and emergency cesarean section were significantly different in patients with HELLP syndrome[(30.56±4.11)vs(30.02±6.00);11% vs 59%;60.5% vs 94.4% respectively,t= 5.563,χ2 = 4.155,7.043,all P< 0.05].Lactate dehydrogenase and total bilirubin were significantly higher in patients with HELLP syndrome[(1 398.94±1 587.49)U/L vs(561.75±304.84)U/L,(33.48±48.86)μmol/L vs(9.70±7.18) μmol/ L,t= 14.717,7.53,all P<0.05].The platelet was obviously lower in patients with HELLPsyndrome[(49.56± 27.14)×109/L vs(207.93±116.68)×109/L,t= 20.762,P< 0.05].There was one patient died in each group and the mortality rate was not different between two groups.In HELLPsyndrome group,2 patients developed acute kidney injury and received renal replacement treatment,which was significantly higher than group without HELLP syndrome (11% vs 0%,χ2= 4.94,P< 0.05). There were more patients accepted transfusion in severe preeclampsia with HELLP syndrome group(61.1% vs 30.2%,χ2= 5.07,P< 0.05). Conclusion The incidence of concurrent severe preeclampsia and HELLP syndrome is not rare for critically ill obstetric patients. The rate of organ dysfunction is high in patients with HELLP syndrome. Key words: Pre-Eclampsia; HELLP Syndrome; Pregnancy Outcome; Intensive Care Unit
Published Version
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