CLINICAL AND NEUROLOGICAL FEATURES OF DYSCIRCULATORY ENCEPHALOPATHY COURSE IN PATIENTS WITH HYPOTHYROIDISM ACCORDING TO THE PROSPECTIVE STUDY DATA

Abstract

Introduction. Chronic insufficiency of cerebral blood circulation, dyscirculatory encephalopathy, takes a prominent place among cerebrovascular pathology. Currently, along with the growth of dyscirculatory encephalopathy, there is an increase in endocrine pathology, such as hypothyroidism. Neurological disorders in hypothyroidism are a severe and widespread condition of the nervous system. Cerebral pathology, which develops as a result of metabolic and vascular disorders in patients with hypothyroidism, is a manifestation of endothelial dysfunction, such as disruption of endothelial function compensation. Aim. The aim of our study was to reveal the clinical and neurological features of dyscirculatory encephalopathy in patients with hypothyroidism according to the prospective study data. Materials and methods. The 60 patients with hypertensive dyscirculatory encephalopathy and accompanying hypothyroidism, who were under supervision for 10 years, were examined with clinical, neurological, neuropsychological, instrumental and laboratory examination. Results. According to the study results, it was proved, that the patients of the second group, i.e. those who were examined at the present time, were more likely to complain of unsteadiness while walking and general weakness. When analyzing the objective neurological symptoms among the patients included in the study, a coordination disorders were established as dominating. At the same time, the II group of patients was characterized by more frequent detection of pathological plantar reflexes, unsteadiness in the Romberg posture and walking ataxia, compared to the I group. When analyzing the objective neurological symptoms, among the patients included in the study, coordination disorders were established as dominating. Conclusions. According to the results of a prospective study, it was proved that hypothyroidism is associated with a more severe course of vestibulo-ataxic syndrome in patients with chronic brain ischemia.