Clinical analysis of half amount triptorelin in patients with endometriosis after operation

Abstract

Objective To analyze half amount triptorelin in patients with endometriosis after application . Methods According to digifal table ,86 patients with endometriosis were randomly divided into the two groups：the observation group（43 cases）and the control group（43 cases）.All patients were treated with laparoscopy .The patients in the observation group were treated through half amount triptorelin ,while the control group was treated through whole amount triptorelin .They were treated for six months .Serum carbohydrate antigen 125 （ CA125 ） and tumor necrosis factor-α（ TNF-α） were measured before and after treatment .Results The groups of patients were successfully operated.The total effective rates in the control group were 97.7%in the control group and 95.3%in the observation group,there was no significant difference （χ2 =1.46,P〉0.05）.1-year follow-up after surgery,the control group had 5 cases of recurrence ,the recurrence rate was 11.6%,the observation group had 4 cases of recurrence ,the recurrence rate was 9.3%,there was no significant difference （χ2 =0.92,P〉0.05）.After treatment,serum CA125 and TNF-αwere significantly lowered,but levels of serum CA125 and TNF-αafter treatment had no significant difference （t=0.773,0.131,P〉0.05）.During treatment,the control group had 15 cases of adverse reactions ,the rate was 34.9%and the observation group had 5 cases of adverse reactions,the rate was 11.6%.The observation group should be significantly less than the control group （χ2 =6.78,P〈0.05）.Conclusion Half amount triptorelin had the quite effect with whole amout and fewer adverse reactions . Key words: Endometriosis; Triptorelin; Postoperative period