Abstract
Objective To explore the clinical features of histoplasmosis in China.Methods The clinical data of 310 patients of histoplasmosis were analyzed retrospectively,which were pooled from legal published periodicals.Results Ratio of male to female was about 2:1(214:96).36(11.6%)patients were immunocompromised hosts.262(84.5%)patients had hyperpyrexia.240(77.4%)patients had hepatomegaly or(and)splenomegaly.86(27.7%)patients were lymphadenectasis.Confirmed caSes made from blood smear or(and)bone marrow slides,autopsy,biopsy of lymph node or(and)exploratory laparotomy,open lung biopsy,percutaneous lung puncturation and sputum culture were 234(75.5%),6,36,26,6 and 2 respectively.307(99.03%)patients were infected by histoplasma capsulatum except 3 patients infected by histoplasma duboisii.Among the 310 patients,269 were disseminated infection,34 were pulmonary histoplasmosis,7 were other focal type.275(88.7%)patients received antifungal therapy.257(82.9%)patients were cured and 53(17.1%)patients had no response to therapy because of their severe condition.The eastern and southern areas of China were the main endemic region of histoplasmosis.Conclusion In China,histoplasma eapsulatum infection occurs more often than histoplasma duboisii.The disease has gender difference.Most of the patients are in their normal immune conditions.Hyperpyrexia,hepatomegaly,splenomegaly and lymphadenectasis are the dominant clinical manifestations.The misdiagnosis rate is high.Histopathology is the main method of diagnosis.Most patients have good response to antifungal therapy.The rate of traatment failure is 17.1%.The histoplasmosis occurs more often along the coast of southern and eastern in Chinese mainland. Key words: Histoplasma; Infection; Retrospective study
Published Version
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