Abstract
Mantle cell lymphoma (MCL) is regarded as an incurable neoplasm, even to the novel drug strategies. It is known MCL has two morphological variants- classic and aggressive. Aggressive MCL is characterized by a higher mitotic index and proliferation rate, and poor overall survival in comparison to classic subtype. The insight into the detailed biochemical composition of MCL is crucial in the further development of diagnostic and treatment guidelines for MCL patients; therefore Synchrotron radiation Fourier Transform Infrared (S-FTIR) microspectroscopy combined with Principal Component Analysis (PCA) was used. The major spectral differences were observed in proteins and nucleic acids content, revealing a classification scheme of classic and aggressive MCLs. The results obtained suggest that FTIR microspectroscopy has reflected the histopathological discrimination of both MCL subtypes.
Highlights
Mantle cell lymphoma (MCL) is regarded as an incurable neoplasm, even to the novel drug strategies
The purpose of the current study was to determine differences between classic and aggressive mantle cell lymphomas using Synchrotron radiation Fourier Transform Infrared (S-Fourier Transform Infrared (FTIR)) microspectroscopy combined with Principal Component Analysis (PCA) analysis of the acquired spectroscopic data
This research has demonstrated that the histopathological subtyping of MCL into classic and aggressive forms has its strong background in the biochemical landscape of both subtypes
Summary
Mantle cell lymphoma (MCL) is regarded as an incurable neoplasm, even to the novel drug strategies. It is known MCL has two morphological variants- classic and aggressive. Aggressive MCL is characterized by a higher mitotic index and proliferation rate, and poor overall survival in comparison to classic subtype. It is already known that MCL is a heterogeneous disease and distinct morphological variants have been described These encompass classic and aggressive (blastoid and pleomorphic) mantle cell lymphomas[2,3,4]. The classic MCL is characterised by lower mitotic index and lower proliferation rate (Ki67/MiB-1 index) in comparison to both aggressive subtypes[5]. The MCLs classification is well-established with histopathological assessment, the insight into the molecular/biochemical information would be invaluable for a better description of both entities and would be a fundamental proof for the validity of their classification
Sign-in/Register to view highlights & summary 
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call