Circulatory RNA based non-invasive detection and diagnosis of breast cancer

Abstract

Breast carcinoma is the most prevalent and lethal form of carcinoma in women, as well as the most prominent source of cancer-related mortality in women. The most widespread form of non-invasive breast carcinoma is ductal carcinoma in situ (DCIS). Early detection of breast carcinoma improves the chances of rehabilitation and survival, lowering mortality rates. Limitations of mammography as a screening test have made it imperative to develop new, non-invasive, and more convenient alternatives for the prognosis of breast carcinoma. Circulatory RNAs (miRNAs) have been included in a novel category of non-coding, endogenous, small RNA fragments that can be considered gene expression regulators, influencing key processes in cancer development. Peculiar expressions and firmness of circulatory RNAs exhibit a promising possibility of their use as biomarkers in the prognosis of mammary tumor.