Circulating CXCL16 in type 2 diabetes mellitus Egyptian patients

Abstract

ABSTRACT Background Type 2 diabetes mellitus (T2DM) is an international health concern. The C-X-C chemokine ligand 16 (CXCL16) functions as a scavenging cell surface receptor. Vitamin D3 has vital effects on inflammation and insulin homeostasis. Purpose To investigate the significance of serum CXCL 16 and vitamin D3 in T2DM patients to understand disease pathophysiology. Materials and Methods The current work was performed as a cross-sectional study. The study included 60 participants, 30 patients with T2DM attending the national institute of diabetes clinics and 30 age and sex-matched healthy controls. Participants underwent the following: Serum CXCL16 by enzyme-linked immunosorbent assay (ELISA), vitaminD3 by radioimmuno assay(RIA), glycosylated hemoglobin (HbA1c), fasting blood sugar(FBS), thyroid stimulating hormone (TSH), liver and kidney functions. Results and discussion Serum CXCL16 levels were significantly higher and serum vitamin D3 levels were significantly lower in T2DM patients compared to controls (p < 0.00001). Serum CXCL16 levels correlated negatively with vitamin D3 levels (r = – 0.837 and p = 0.00001) while a negative correlation was recognized between vitaminD3 levels and HbA1c % in patients (r = −0.609 and p = 0.00035). Conclusion Serum CXCL16, vitamin D3 and HbA1 c may be important parameters in monitoring T2DM and predicting complications.