Abstract
The aim of the study was to establish the circadence dynamics of metabolic, bile secretion processes in female and male rats. The chronopharmacology study with blood sampling in experimental rats four times of day (3 am, 9 am, 3 pm and 9 pm) was carried out. As a result of the conducted investigation it was established the existence of circadian fluctuations in the general protein, albumin, cholesterol, general bilirubin levels and activity of alkaline phosphatase and the absence of a clear circadence dynamics of the content of urea and uric acid in blood serum. Significant differences between male and female rats was not revealed. The results of circadence organization of metabolic and bile secretion processes in rats should be taken into account in analyzing of hepatoprotectors and other drugs' chronoformname.
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