Abstract
Thalidomide is the drug of choice for erythema nodosum leprosum (ENL) in men. Its use in patients with multiple myeloma has been reported to cause venous thrombosis. Postulated mechanism is an increase in procoagulant state with the use of thalidomide along with corticosteroids in the underlying hyperviscosity in multiple myeloma. We report a case of superficial and deep vein thrombosis and chronic pulmonary vein embolism in a patient of ENL treated with thalidomide and corticosteroid. An increase in procoagulant state with the use of these two medicines along with a persistent inflammatory state in ENL and an increased risk of venous thrombosis in type 3 hypersensitivity together may have resulted in thrombus formation.
Published Version
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