Abstract
SUMMARYThe effect of 8-azaguanine (5 × 10−4M) on the root meristems of Pisum sativum has been studied.The immediate effect of 8-azaguanine is an inhibition of interphase (G2) nuclei to enter mitosis ending in the absence of mitosis after a 12-hour treatment. Inhibition of DNA synthesis (H3-thymidine incorporation) starts to appear after 6 hours: 8-azaguanine does not interfere with DNA synthesis once it is initiated, but it inhibits the initiation of DNA synthesis (passage from G1 to S) at least in the majority of cells (data of the DNA cyto-photoinetry).When roots treated with 8-azaguanine for 17 hours recover in water for 24 hours, both diploid (14 monochromosomes) and endotetraploid (14 diplochromosomes = 4-chromatid chromosomes) mitoses are found in the meristem. The proportion of diplochromosome mitoses is still higher when the 24-hour water recovery follows two 8-azaguanine treatments, 17-hours each, separated by a 6-hour root immersion in 5 x 10—4M guanine. A treatment has also been found which ind...
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