Abstract
THE response of the carotid body of the cat to the stimuli of hypoxia and hypercapnia is indicated by a large increase in signal traffic in the afferent nerve, but the transducer mechanism is unknown. There are two principal schools of thought, one proposing the involvement of an adrenergic mechanism, the other a cholinergic mechanism. Among the evidence for the cholinergic mechanism is the response of the carotid body to local injections of acetylcholine, which cause an increase in the afferent nerve impulses1. Recently acetylcholine, or a very similar substance, has been found in the carotid body in considerable amounts2.
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