Abstract
Persistent and recurrent bacterial infections pose significant challenges during the repair and reconstruction of bone defects, necessitating the development of effective solutions to this problem. Herein, a chlorine dioxide delivery platform (LDH@Cl) comprising chlorite-incorporated clay nanosheets (MgFe layered double hydroxides, MgFe LDH) is designed and constructed. The LDH@Cl gas bomb exploits self-promoted chemical reactions in an acidic and H2O2-rich microenvironment, generating substantial amounts of ClO2 and ·OH, which exhibit potent antibacterial activity. LDH@Cl exhibits half-maximal inhibitory concentrations of 0.69 mM and 0.78 mM against Escherichia coli and Staphylococcus aureus, respectively. Furthermore, LDH@Cl exhibits good biocompatibility at a low concentration of 0.08 mM; and significant osteogenic induction effects at a high concentration of 0.8 mM, which is attributed to the release of Mg ions and Fe ions in a normal microenvironment. Furthermore, LDH@Cl promotes the expression of the osteogenic channel signaling protein BMP2, which stimulates the expression of the downstream signaling factors SMAD1, SMAD2, and SMAD3, thereby regulating the synthesis of osteogenic-related proteins. Importantly, in vivo studies demonstrate the positive therapeutic effects of LDH@Cl in bacterial eradication and accelerated osteogenesis. Thus, this novel nano “gas bomb” is promising for the clinical treatment of bacterial infection related bone defect regeneration.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.