Abstract
A new high yielding protocol has been developed for the convenient and rapid synthesis of 2-amino-4H-pyrans by one-pot sequential reaction of aldehydes, malononitrile and cyanoketones in aqueous micellar medium using chitosan as an efficient heterogeneous, biodegradable and reusable green catalyst. Mild conditions with excellent conversions, cost effectiveness, short reaction times, environmental friendliness, and operational simplicity are noteworthy advantages of this method. The micellar catalytic system can be reused several times without any noticeable decrease in its activity.
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