Abstract
AbstractAn efficient and straightforward synthetic strategy for pharmaceutically pertinent scaffold 4,5‐dihydro‐1H‐pyrazole has been reported initiating from highly substituted chalcones (1) and thiosemicarbazide (2) as reactants in an aqueous micellar medium by the use of DBU (1,8‐Diazabicyclo[5.4.0]undec‐7‐ene) as an organobase. The use of CTAB (Cetyl Trimethyl Ammonium Bromide) as a surfactant, which forms a colloidal dispersion with organic substrates with the enhancement of the reactivity of substrates is the key feature of this technique. Organic synthesis in aqueous micellar medium, use of organocatalyst DBU, mild reaction conditions, sustainable synthesis, experimental feasibility, broad substrate scope, short reaction time and high yields are some other attributes of this protocol.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
