Abstract
One-pot synthesis of Hantzsch 1,4-dihydropyridines (1,4-DHP) under solvent-free conditions catalyzed by HKUST-1 metal-organic frameworks are reported here. This method provides 1,4-dihydropyridines in good to excellent yields with little catalyst loading. The present methodology offers several advantages, including ease of the preparation and handling of the catalyst, simple and easy work-up, short reaction times, high yields of the products and recyclability of the catalyst. One-pot synthesis of Hantzsch 1,4-dihydropyridines (1,4-DHP) under solvent-free conditions catalyzed by HKUST-1 metal-organic frameworks are reported here. This method provides 1,4-dihydropyridines in good to excellent yields with little catalyst loading. The present methodology offers several advantages, including ease of the preparation and handling of the catalyst, simple and easy work-up, short reaction times, high yields of the products and recyclability of the catalyst.
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