Chitosan-Based Nanoparticles of Targeted Drug Delivery System in Breast Cancer Treatment.

Yedi Herdiana,I Made Joni,Muchtaridi Muchtaridi,Shaharum Shamsuddin,Nasrul Wathoni

doi:10.3390/polym13111717

Yedi Herdiana, I Made Joni + Show 3 more

Open Access

https://doi.org/10.3390/polym13111717

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Journal: Polymers	Publication Date: May 24, 2021
Citations: 83	License type: CC BY 4.0

Affiliation: Padjadjaran University, Universiti Sains Malaysia

Abstract

Breast cancer remains one of the world’s most dangerous diseases because of the difficulty of finding cost-effective and specific targets for effective and efficient treatment methods. The biodegradability and biocompatibility properties of chitosan-based nanoparticles (ChNPs) have good prospects for targeted drug delivery systems. ChNPs can transfer various antitumor drugs to targeted sites via passive and active targeting pathways. The modification of ChNPs has attracted the researcher to the loading of drugs to targeted cancer cells. The objective of our review was to summarize and discuss the modification in ChNPs in delivering anticancer drugs against breast cancer cells from published papers recorded in Scopus, PubMed, and Google Scholar. In order to improve cellular uptake, drug accumulation, cytotoxicity, and selectivity, we examined different kinds of modification of ChNPs. Notably, these forms of ChNPs use the characteristics of the enhanced permeability and retention (EPR) effect as a proper parameter and different biological ligands, such as proteins, peptides, monoclonal antibodies, and small particles. In addition, as a targeted delivery system, ChNPs provided and significantly improved the delivery of drugs into specific breast cancer cells (MDA-MB-231, 4T1 cells, SK-BR-3, MCF-7, T47D). In conclusion, a promising technique is presented for increasing the efficacy, selectivity, and effectiveness of candidate drug carriers in the treatment of breast cancer.

Highlights

Breast cancer is the most common, chronic, and common causes of invasive and death in women worldwide [1,2,3], in both developing and advanced countries [4]
The nanoparticles can be classified into three groups according to the difference in the preparation method
While targeted drug delivery systems with a controlled release profile have recently developed, certain restrictions such as premature and low release of chemical agents into the target cell of cancer can limit the in vivo impacts of such modalities [87,88]

Summary

Introduction

Breast cancer is the most common, chronic, and common causes of invasive and death in women worldwide [1,2,3], in both developing and advanced countries [4]. The lack of available treatment options for advanced cancer stages is the primary explanation for the highest cancer mortality rate [6]. Different therapeutic methods have been licensed for the treatment of this disease regardless of the stage of the disease, but the value of specific conventional techniques reduces due to the dynamic and heterogeneous nature of the cancer tissue [1]. Tumor eradication surgery followed by radiation and chemotherapy were conventional methods of treatment that often caused many harmful side effects on healthy cells [6,7,8]. There is a high recurrence rate for most treatments, so the search for effective anticancer agents continues [9]

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Conclusion