Chiral Sulfinyl-Based Olefin Ligands for Rhodium-Catalysed Asymmetric Conjugate Addition of Arylboronic Acids to Cyanoalkenes

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A rhodium/sulfinyl-based olefin ligand-catalysed asymmetric conjugate addition of arylboronic acids to cyanoalkenes without activation groups has been developed, where p-tolylsulfinyl-functionalised olefin ligands have been shown to be effective and with moderate enantioselectivities. This is the first example of applying chiral sulfinyl-based olefin ligands in the catalytic asymmetric addition to cyanoalkenes.