Abstract
Cyperaceae is a cosmopolitan plant family with approx. 5000 species distributed worldwide. Several members of this family are used in traditional medicines for the treatment of different diseases. In the last few decades, constituents with great chemical diversity were isolated from sedges, and a wide range of biological activities were detected either for crude extracts or for pure compounds. Among the isolated compounds, phenolic derivatives are the most important, especially stilbenoids, and flavonoids. To date, more than 60 stilbenoids were isolated from 28 Cyperaceae species. Pharmacological investigation of Cyperaceae stilbenoids revealed that several compounds possess promising activities; mainly antiproliferative, antibacterial, antioxidant and anthelmintic effects. Isolation, synthesis and pharmacological investigation of stilbenes are increasing constantly. As Cyperaceae species are very good sources of a wide variety of stilbenes, and several of them occur in large amount worldwide, they are worthy for phytochemical and pharmacological investigations. Moreover, stilbenes are important from chemotaxonomical point of view, and they play a key role in plant defense mechanisms as well. This review summarizes the stilbenoids isolated from sedges, and their biological activities.
Highlights
Horváth Györgyi and Cyperaceae is a cosmopolitan family of monocot plants with approximately 100 genera and 5000 species
Many Cyperaceae species are considered to be undesirable weeds, and their presence is of particular economic importance in some regions [7], sedges have several traditional applications by humans; edible species are consumed as nutritional supplemental food, others are used for weaving household items and several species for their medicinal properties
According to the literature data, plants belonging to the family Cyperaceae are rich sources of stilbenoids
Summary
In the last few decades, constituents with great chemical diversity were isolated from sedges, and a wide range of biological activities were detected either for crude extracts or for pure compounds. Phenolic derivatives are the most important, especially stilbenoids, and flavonoids. More than 60 stilbenoids were isolated from 28 Cyperaceae species. Pharmacological investigation of Cyperaceae stilbenoids revealed that several compounds possess promising activities; mainly antiproliferative, antibacterial, antioxidant and anthelmintic effects. Synthesis and pharmacological investigation of stilbenes are increasing constantly. As Cyperaceae species are very good sources of a wide variety of stilbenes, and several of them occur in large amount worldwide, they are worthy for phytochemical and pharmacological investigations. This review summarizes the stilbenoids isolated from sedges, and their biological activities. Molecules 2021, Keywords: Carex; Cyperus; Scirpus; resveratrol; stilbenoid dimers; oligostilbenoids; antiproliferative; antioxidant; anthelmintic activity
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