Abstract

Since ancient times human utilized the nature to cure various ailments. The knowledge of medicinal plants resulted in the development of various indigenous systems of medicine worldwide. Serendipitous discovery as well as scientific approach on the reason for medicinal properties of plants gave the knowledge of chemical constituents such as secondary metabolites in plants. Wrightia tinctoria which is commonly known as ‘Danthapala’ is a known potential medicinal plant, the leaves of which is traditionally used in the treatment of psoriasis and non-specific dermatitis in Siddha and Ayurvedic systems of medicine and distributed in tropical region belongs to the family Apocynaceae. This plant is beneficial for the treatment of dandruff, various scalp and skin disorders. Phytochemical and pharmacological investigation on the various parts of the plant showed anti-ulcer, anti-inflammatory, analgesic, anthelmintic, anti-cancer, anti-dandruff, wound healing and anti-anxiety activity. The current review focus on providing an update on the recent pharmacological and phytochemical investigations on the plant by researchers around the globe with special emphasis on Antisporiatic, Antifungal, Antibacterial, Antiviral, Cytotoxic, Anti-inflammatory, Anti-diabetic, Analgesic, Hepatoprotective, Anthelmintic, and Wound healing activities.

Highlights

  • Wrightia tinctoria (Roxb) R.Br is comparatively a small deciduous tree, bark is scaly and smooth, young parts are glabrous or puberulous

  • The intention of the current review is to explore different parameters of plant like general description, distribution, chemical constituents, traditional uses and to highlight pharmacological activities studied in recent literatures

  • When the leaves of this plant is kept in a glass of coconut oil for a few hours, the oil slowly turns blue in colour The name indicates this property of Wrightia tinctoria

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Summary

INTRODUCTION

Wrightia tinctoria (Roxb) R.Br is comparatively a small deciduous tree, bark is scaly and smooth, young parts are glabrous or puberulous. 7.5-15 cm in length and 2.5-5.7cm in width, shape is elliptic, lanceolate, apex is acuminate, surface glabrous or the young leaves puberulous, base acute or rounded, main nerves 6-12 pairs, petioles are 3-4mm in length. Flowers are white and fragrant, arranged in lax terminal cymes about 12.5cm diameter with slender dichrotomous branches; minute ovate bracts, glabrous calyx, glandular inside; segments 2.5mm in length, oblong, apex rounded and with membranous margins. The intention of the current review is to explore different parameters of plant like general description, distribution, chemical constituents, traditional uses and to highlight pharmacological activities studied in recent literatures. The search strategy adopted for this purpose focused on the databases like pubmed, scopus and web of science from inception to 2021

Seasons
PHARMACOLOGICAL STUDIES
Anticancer Activity
Antimicrobial Activity
Antiulcer Activity
Antidiabetic Activity
Antifungal Activity
Post Coital Interceptive Activity
2.10 Antioxidant Activity
Antipsoriatic Activity
2.11 Anthelmintic Activity
2.12 Antinociceptive Activity
2.13 Hepatoprotective Activity
2.14 Antiviral Activity
2.15 Immunomodulatory activity
2.16 Absence of Central Activity
2.17 Antispasmodic and Antidiarrhoeal Activity
2.18. Larvicidal Activity
PHYTOCHEMISTRY
Phytochemical Studies
Evaluation of Hepatoprotective Activity of
Phytochemical and Pharmacological
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