Abstract
4-Hydroxycoumarin derivatives include a number of compounds exhibiting biological activity. An important place in this series is occupied by furocoumarins possessing diverse pharmacological properties: antifungal, zoocidal, anticoagulant, spasmolytic, etc. [1–6]. Furocoumarins can be isolated from natural sources [7] or synthesized [8–11]. Methods of synthesis of furocoumarins are based on C-alkylation of 4-hydroxycoumarin with α-halo ketones or halo alkynes with subsequent cyclization [9, 10] or on oxidative addition of olefins to 4-hydroxycoumarin in the presence of silver(I) salts [11].
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