Abstract
Some new principles for the development of novel “biomimetic sensors” are discussed that are based on the mechanisms of molecular recognition and information transduction/amplification at biological cell membranes, displayed by receptors, active transport carriers, and ion-channels. Thus, the development of a potentiometric sensor for organic anions and neutral molecules using macrocyclic polyamine as a sensory element, the generation of membrane potential at lipid bilayers by neutral hydrophobic odorants, and some new strategies for sensors with built-in signal transduction/amplification functions (uphill transport membrane sensors and ion-channel sensors) are described.
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