Abstract

Chemical genomics and molecular medicine

Highlights

  • Mycobacterium tuberculosis (Mtb) is the etiologic agent of tuberculosis and infects *32% of the human population

  • polyketide synthases (PKSs) are generally involved in the synthesis of secondary metabolites in various organisms and their role in biosynthesis of virulence factors is unprecedented

  • Due to overlapping substrate specificities and cofactor requirements of various enzymes involved in lipid biosynthesis, directed synthesis of chemical compounds targeting multiple pathways could provide new avenues for drug discovery. 089: A high-throughput generation of natural product-inspired compounds: The discovery of chemical modulators of cell death pathways involving Bcl-XL/Mcl-1

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Summary

Introduction

Mycobacterium tuberculosis (Mtb) is the etiologic agent of tuberculosis and infects *32% of the human population. Due to overlapping substrate specificities and cofactor requirements of various enzymes involved in lipid biosynthesis, directed synthesis of chemical compounds targeting multiple pathways could provide new avenues for drug discovery. 089: A high-throughput generation of natural product-inspired compounds: The discovery of chemical modulators of cell death pathways involving Bcl-XL/Mcl-1

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