Abstract
The neem plant (Azadirachta indica) is a herb with the potential as a source of antioxidants. This study aimed to identify compounds that exist in the neem leaf and determine their antioxidant activity. Neem leaf extract was collected by using 80% methanol. Furthermore, methanol extracts from neem leaves with the highest antioxidant activity were partitioned with n-hexane, ethyl acetate, and water. This research were analyzed by partition for antioxidant activity, and DPPH (1,1-diphenyl-2-pycrilhydrazil) and the half-maximal inhibitory concentration (IC50) values were determined. The results showed that the ethyl acetate partition had the highest antioxidant activity, with IC50 values of 1.004 µg/ml. Neem leaf extract has the potential for a use as an herbal medicine in the treatment of various diseases..
Highlights
Neem is a plant in the family Meliaceae (Dash, Dixit, & Sahoo 2017 ) that can be found in tropical countries such as India and Indonesia (Igwenyi et al 2017)
Acetate has a higher antioxidant activity than the fractions of n-Hexane and water. This is because ethyl acetate is a semi-polar solvent, and as such, it can attract polar and non-polar compounds
The results revealed that neem leaf extracts contained bioactive compounds, such as tannins, saponins, flavonoids, and terpenoids, and had strong antioxidant activity
Summary
Neem is a plant in the family Meliaceae (Dash, Dixit, & Sahoo 2017 ) that can be found in tropical countries such as India and Indonesia (Igwenyi et al 2017). Neem plants in Indonesia were first encountered as shade plants. Neem tree trunks can grow to 20 m tall and have a slightly rough stem and oval-shaped leaves with jagged edges, with pointy stone fruit measuring 1 cm in length. Neem plants have the potential for use as an herbal remedy and are known in India as the God of Plants because it can cure various diseases. Neem plant parts used as herbal remedies were the stem, seeds, and leaves (Susmitha et al, 2013). The leaves and bark of neem plants can be applied in the pharmaceutical field as a source of natural antioxidants and medicine (Sithisarn et al 2005; Altemimi et al 2017; Heyman et al 2017)
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