Characterizing Neutrophil Subtypes in Cancer Using scRNA Sequencing Demonstrates the Importance of IL1β/CXCR2 Axis in Generation of Metastasis-specific Neutrophils.

Alistair Mclaren,Andrew D Campbell,Cassie J Clarke,Colin Nixon,Colin W Steele,Declan Whyte,Jim C Norman,John Falconer,Kathryn Gilroy,Kristina Kirschner,Leo M Carlin,Mark White,Megan L Mills,Owen J Sansom,Rachel A Ridgway,Rana Fetit,Rene Jackstadt,Renee Njunge,Tamsin Rm Lannagan,Varushka Naiker,Xabier Cortes-Lavaud

doi:10.1158/2767-9764.crc-23-0319

Characterizing Neutrophil Subtypes in Cancer Using scRNA Sequencing Demonstrates the Importance of IL1β/CXCR2 Axis in Generation of Metastasis-specific Neutrophils.

Alistair Mclaren, Andrew D Campbell + Show 19 more

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https://doi.org/10.1158/2767-9764.crc-23-0319

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Journal: Cancer research communications	Publication Date: Feb 29, 2024
Citations: 1	License type: CC BY 4.0

#Subtypes In Cancer #Immunotherapeutic Approaches #Neutrophil Subtypes #scRNA Sequencing #Neutrophil Populations

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We identify two recurring neutrophil populations and demonstrate their staged evolution from health to malignancy through the IL1β/CXCL8/CXCR2 axis, allowing for immunotherapeutic neutrophil-targeting approaches to counteract immunosuppressive subtypes that emerge in metastasis.

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Characterizing Neutrophil Subtypes in Cancer Using scRNA Sequencing Demonstrates the Importance of IL1β/CXCR2 Axis in Generation of Metastasis-specific Neutrophils.