Abstract
<p>Signaling patterns in CRCLM. <b>A</b> and <b>B,</b> Outgoing and incoming signaling patterns in CRCLM. <b>C,</b> Cellular roles as dominant senders (sources) and receivers (targets) in CRCPT and LM. CRCPT dataset did not contain any Tregs or neutrophils. <b>D,</b> UMAP plot of neutrophil subtypes in CRCLM. <b>E,</b> Interaction strength of the global communication patterns between neutrophil, T-cell, and macrophage subtypes. <b>F–I,</b> Outgoing signal strengths from TXNIP+ neutrophils, SPP1+ macrophages, M1- and M2-like macrophages, respectively. <b>J,</b> The contribution of each L-R pair to the overall CXCL signaling pathway among macrophage, neutrophil, and T-cell subtypes. <b>K–M,</b> Visualization of the cell-cell communication patterns mediated by the most significant L-R pairs in CXCL pathway. <b>N,</b> Heat map showing the relative strengths of the significant outgoing and incoming signaling patterns in all communication pathways with dominant sender and receiver immune cell subtypes. The top colored bar plot represents the sum of column of values displayed in the heat map representing the different cell populations. The right gray bar plots represents the sum of row of values, representing the different signaling pathways.</p>
Submitted Version
Published Version
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