Abstract
Wild type HIV-1 CA protein can spontaneously assemble into long, hollow tubes at high salt (1M NaCl) and high protein (10mg/ml) concentration. These tubes are structural mimics of the mature capsid, and Cryo EM has revealed that they are composed of CA hexamers. Although WT CA tubes are unstable under low salt and low protein concentrations, a specific double cysteine mutation that efficiently cross-links the CA hexamers, dramatically stabilizes the assemblies under a variety of conditions. We are interested in studying the structure of these CA tubes under physiological conditions.
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