Abstract
Both deoxyribose moieties and phosphodiester bonds of DNA are destroyed by the action of bleomycin. A malonic aldehyde-like compound is produced in the drug-treated DNA. Phosphodiester bond rupture results in the production of 30 % of hydroxyl groups and 70 % of phosporyl groups in the 5′-termini of bleomycintreated DNA. Very few or perhaps none of the 3′-termini are phosphorylated.
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