Characterization, bioactivity, sustained release capacity and digestive stability of acidic sugarcane leaf polysaccharide liposomes

Abstract

Acidic sugarcane leaf polysaccharide (ASLP) has a variety of biological activities, but its macromolecular properties make it difficult for the human body to completely absorb or metabolize quickly in the body, and the action time is short. To solve this problem, acidic sugarcane leaf polysaccharide liposomes (ASLPL) were prepared by reverse evaporation method and characterized for encapsulation efficiency, particle size, potential, morphology, rheology and stability. In vitro release and digestion tests were used to verify the sustained release effect and stability of ASLPL. The results showed that ASLPL was spherical, with an encapsulation rate of 86.19% ± 0.976%, a particle size of 134.57 ± 2.501 nm, and a zeta potential of −24.49 ± 1.002 mV, which was a pseudoplastic fluid that was more stable to be stored in a neutral environment at 4 °C. The antioxidant, hypolipidemic and antibacterial activities of ASLPL were significantly increased compared with those of ASLP. The in vitro release and digestion results showed that ASLPL had obvious sustained release effect and could slow down the digestion of ASLP in vivo and prolong the duration of action. Therefore, the development and utilization of ASLPL can provide a greater development potential for the further application of ASLP in the food and pharmaceutical fields.