A study on PLGA sustained release icariin/titanium dioxide nanotube composite coating.

Abstract

The Chinese medicine icariin with osteoinduction and osteogenesis abilities is loaded onto the surface of TiO2 nanotubes to form icariin/TiO2 nanotube composite coating, which can synergistically enhance the osseointegration around the implant. However, the half-life of icariin is short, and the sustained release effect of TiO2 nanotubes cannot meet the long-term stable drug release requirement. Therefore, in order to enhance the sustained release effect of icariin/TiO2 nanotube composite coating, in this study, polymer PLGA was applied to the composite coating by overlay method and mixing method. Scanning electron microscopy and release detection were performed to study the effects of two PLGA loading methods on the loading and early release of composite coatings. Results showed that the PLGA loading and sustained release effect was stronger than that of TiO2 nanotubes. The sustained release effect was mainly manifested in the rapid release phase. The release time of the TiO2nanotube drug-loaded composite coating was 9 days. Overlay method and mixing method extended the drug release time to 12 d and 10 d, respectively. Therefore, PLGA can enhance the loading and sustained release properties of icariin/TiO2 nanotube composite coating. Overlay method has better sustained release effect, and the mixing method has better loading performance.