Abstract
1. 1. Blood samples were withdrawn from different areas, i.e. from splenic vein (exit of primitive intrasplenic islet), pancreatic vein, portal vein and abdominal vein (peripheral venous level). 2. 2. Plasma somatostatin levels were estimated in all regional samples by radioimmunoassay. Splenic vein values (2642 ± 285 pg/ml) were markedly higher than those of pancreatic vein (1741 ± 247 pg/ml) and a negative gradient was observed between portal and peripheral plasma levels. 3. 3. Serial dilution displacement curves and gel-chromatography of extracted plasma revealed that circulating somatostatin was heterogeneous. A high molecular weight form appeared predominant in all the areas studied. This “large” form, eluted in fractions close to synthetic somatostatin-28, seemed to be the single molecular form present in splenic vein while in pancreatic and abdominal veins two components of somatostatin-28 and -14 molecular size can be observed. 4. 4. Results are discussed from a phylogenetic point of view and focused on high levels and high molecular forms of somatostatin in blood issued from primitive pancreatic structures.
Published Version
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