Gel filtration profile of plasma active and inactive renin in normals and patients with nephrotic syndrome

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The molecular weight of plasma renin from healthy subjects and patients with nephrotic syndrome, in whom we previously reported that plasma inactive renin was increased, was studied by gel filtration. Activation was performed by acid treatment. The plasma from healthy subjects contains a low molecular weight form of renin (40 000) and a high molecular weight form which can be separated into two peaks of 52000 and 60000. After acid activation, renin activity was increased in the high molecular form but not significantly in the low molecular form. Although the increase of renin activity in the high molecular weight form after acid activation was larger in patients with nephrotic syndrome, the gel filtration profile was similar to that of healthy subjects.