Characteristics of vaginal microecological distribution in cervicitis with HPV infection and observation on therapeutic effect of interferon

Abstract

Objective To investigate the characteristics of vaginal microecological distribution in cervicitis complicated with human papillomavirus (HPV) infection and the effect of interferon therapy. Methods 58 patients with cervicitis and HPV infection admitted to our hospital from May 2017 to May 2018 were selected as study group (they were divided into group A and group B with simple random number table method, 29 cases in each group). 42 patients with simple cervicitis were selected as control group. The patients in group B received compound seabuckthorn seed oil suppository treatment, and the patients in group A received recombinant human interferon α-2b gel. The vaginal microecological distribution characteristics of the study group and the control group were analyzed, and the effects of group A and B were compared. Results The rates of Candida positive, degree 3 to 4 vaginal cleanliness, little lactobacilli in the study group were higher than those in the control group (P 0.05). After treatment, the time of wound healing, vaginal bleeding, and vaginal discharge of group A were significantly shorter than those of group B (P<0.05). The total effective rate was 93.10% in group A, which was better than 72.41% in group B (P<0.05). Conclusion The vaginal cleanliness of patients with cervicitis complicated with HPV infection is poor, Candida infection increases, Lactobacillus decreases, and recombinant human interferon alpha-2b is effective, which is worthy of clinical application. Key words: Cervicitis; Human papillomavirus infection; Vaginal microecology; Distribution characteristics; Recombinant human interferon alpha -2b gel; Clinical efficacy