Clinical effects of Paiteling assisted interferon therapy on cervical intraepithelial neoplasia

Abstract

Objective To investigate the effects of Paiteling assisted interferon therapy on vaginal microecology and vaginal lavage fluid interleukin-10 (IL-10) and interferon-γ (IFN-γ) levels of cervical intraepithelial neoplasia (CIN) I-III. Methods A total of 145 CIN patients treated in Linyi Traditional Chinese Medicine Hospital from August 2016 to February 2018 were randomly divided into Paiteling group (interferon+ Paiteling, n=73) and interferon group (interferon, n=72). The infection of human papillomavirus (HPV), CIN efficacy, vaginal microecology, vaginal lavage fluid IL-10 and IFN-γ were compared between the two groups after 3 months of treatment. Results The HPV infection and CIN efficacy in Paiteling group were significantly better than those in interferon group (P<0.05). After treatment, the detection rate of vaginal pathogens and level of vaginal lavage fluid IL-10 were significantly decreased (P<0.05); while the detection rate of lactobacillus, vaginal pH<4.5 proportion and vaginal lavage fluid IFN-γ level were significantly increased (P<0.05), and the improvement degrees in Paiteling group were greater than those in interferon group (P<0.05). Conclusions Paiteling assisted therapy has exact efficacy on CIN I-III, which can improve the patient’s vaginal microecology, and regulate vaginal the IL-10 and IFN-γ levels. Key words: Cervical intraepithelial neoplasia; Vaginal microecology; Paiteling; Interferon-γ