Abstract
It is well known that the immune system is actively involved in the regeneration and healing process of burn wounds. However, unanswered questions remain about the role of humoral immunity in the mechanisms of healing and complications of burn wounds. We have developed an experimental model of the acid burns of the esophagus (ABE) corresponding esophageal burns in children 1-8 years. We studied the features of humoral immunity in rats with AВE, with the observed reduction of IgG and increase levels of medium and low circulating immune complexes (CIC) on the first day after the burn of the esophagus. On the 21st day after the burn, we observed an increase in the concentration of IgG and a slight accumulation of medium- and low-CIC. Studied indicators can be used for the differentiation of ABE.
Highlights
Burns of the esophagus is one of the most challenging health problems
We have developed an experimental model of the acid burns of the esophagus (ABE) corresponding esophageal burns in children 1-8 years
We studied the features of humoral immunity in rats with AВE, with the observed reduction of IgG and increase levels of medium and low circulating immune complexes (CIC) on the first day after the burn of the esophagus
Summary
Burns of the esophagus is one of the most challenging health problems. According to statistics, 70% of patients – children, whose ages ranged from 1 to 10 years. In severe burns occurs denaturation of proteins in the underlying tissues, reduces synthesis of interferon and opsonization bacteria, inhibits proliferation and reduces cytotoxic activity and chemotaxis of lymphocytes, disrupts reticuloendothelial system develops burn disease with frequent development of secondary immunodeficiency, the severity of which is directly proportional to the depth and prevalence of burns [10]. This depletes humoral immunity and developing autoimmune reactions that lead to increased content in serum circulating immune complexes
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