Abstract
It is well known that the immune system has been actively involved in the regeneration and healing processes of post burn wounds. However, unanswered questions remain concerning the role of humoral immunity in the healing mechanisms and development of burn wound complications. We have developed an experimental model of chemical esophageal burn (CEB) which corresponds to esophageal burn in 1-8 years old children. We studied the features of humoral immunity upon CEB in rats. A decrease in IgG levels and an increase in levels of medium- and low- molecular circulating immune complexes (CIC) on the first day of esophageal burns were observed. On the 21st day of burn, we observed an increase in the IgG concentration and a tendency to accumulation of medium- and low-molecular CIC. The studied indicators can be used to differentiate CEB development and create a timeline of burn wounds.
Highlights
A ccording to the World Health Organization reports, a steady increase in the number of chemical burns of the upper gastrointestinal tract is observed
Chemical burns in animals were experimentally modeled in the following way: alkaline esophageal burn was caused by 10% NaOH (1st degree burns) and 20% NaOH (2nd degree burns), acid esophageal burn was caused by 30% CCl3COOH (2nd degree burns) [9]
Contents of circulating immune complexes (CIC) in the serum were determined by precipitation: macromolecular CIC with 3% polyethylene glycol (PEG), medium molecular CIC with 4.5% PEG, low molecular CIC with 6% PEG (PEG 6000) [11]
Summary
A ccording to the World Health Organization reports, a steady increase in the number of chemical burns of the upper gastrointestinal tract is observed. It is associated with the increa sing production of new chemicals, the continuing production of the concentrated acetic acid and a careless storage of chemicals in daily (domestic) life. It was shown that the level of all immunoglobulin classes increased within two weeks after the chemical burn [5]. It should be noted that the vast majority of researches of the immune system response to burn injury is dedicated to adults, while children immune system response has not been sufficiently studied [7]. The aim of this work was to analyze the distinct features of the immune response and their potential effect on the platelets functioning
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