Abstract
Reactive oxygen species (ROS) serve as important mediators and signaling molecules in many biological processes, but their overproduction can cause or exacerbate disease. This has motivated the development of biomaterials that can interact with ROS in a therapeutic capacity. These ROS-sensitive materials have been primarily used in three broad biomedical applications: (1) ROS-mediated intracellular drug release for targeted delivery to highly oxidative phagocytic or cancerous cells, (2) extracellular drug delivery targeted to tissues with elevated levels of ROS, and (3) the formation of ROS-degradable tissue engineering scaffolds. This chapter outlines the chemistry and function of the different oxidatively responsive polymers currently being researched and describes their functionality in various biomedical applications.
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