Abstract
Inflammation occurs after the in vivo introduction of biomaterials as the body responds to the material and the tissue damage caused by the process of implantation. This chapter describes the inflammatory and foreign body responses to biomaterials and the impact of the physicochemical properties of biomaterials on activating this innate response. Also discussed are the roles of reactive oxygen species produced by biomaterials and surrounding tissues on the initiation, propagation, and remedy of inflammation. In doing so, the relationship between inflammation and oxidative stress and how they help propagate each other will be elucidated. An understanding of this relationship will be helpful in developing strategies to mediate foreign body response and its deleterious effects on implanted biomaterials.
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