Abstract
Alzheimer’s disease (AD) has long been a global health issue with complex pathology. A few bioactive compounds like curcumin showed significant protective efficacy in AD treatment. It showed adequate amyloid beta (Aβ) binding efficacy. Therefore, it has been considered a robust therapeutic agent. However, a few limitations such as poor water solubility, low bioavailability, and short systemic circulation impede its success. To overcome these challenges, an array of drug delivery systems such as polymeric nanoparticles, liposomes, solid lipid nanoparticles, and liquid crystalline nanocarriers were designed, which showed significant enhancement in the therapeutic and targeting efficacy of curcumin. This chapter highlights the therapeutic importance of these drug delivery systems. However, there is still a growing need to develop a robust DDS to accomplish more appropriate therapeutic efficacy.
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