Abstract
The reductionist cell-molecular paradigm for aging implies that the key controls of aging are to be found in such phenomena as free-radical damage, DNA repair, etc. Starting with publications in 1996, such physiologists as M. Djawdan, T.J. Bradley, A.G. Gibbs, A.K. Chippindale, and others continued to probe the biological determinants of the stress resistance shown by P.M. Service and M.R. Rose to underlie the experimental evolution of increased lifespan. The physiological stress resistance characteristics were determined entirely by whole-organism storage of reserve substances and their rates of loss, not cell-molecular mechanisms. By contrast, repeated attempts to find associations between experimentally evolved aging and hypothesized cell-molecular mechanisms of aging failed, though such failures were not published.
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