Abstract
The neurons connecting the optic nerve to the brain are known as ganglion cells which, respond to all common types of neurotransmitters. Retinal neurotransmitter glutamate, excites the ganglion cells through three distinct channels out of which, NMDA receptors (NMDARs) mediate excitatory neural transmission. Ailments such as Alzheimer's, Parkinson's, Glaucoma, and Optic neuropathy are caused by abnormal NMDAR activity, which is associated with loss/death of ganglion cells and therapeutic interventions concerning the same are still being explored. We examined the effect of a vitamin E analogue, trolox and coenzyme Q10 (CoQ10) alone, and in combination against NMDA-induced retinal damage in rats in vivo. The study focuses on the assessment of morphology of ganglion cell layer (GCL) by hematoxylene and eosin staining, toluidene staining, and differential expression of Brn3a marker by immunofluorescence. We present these findings as an interesting prelude, proposing the combination of CoQ10 and trolox as potential therapeutics for curing retinal damage associated with NMDAR mediated neurodegeneration.
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