Abstract
Human amniotic fluid cells have been used as a diagnostic tool for prenatal diagnosis. However, evidence suggests that they may also have therapeutic potential for human diseases, because progenitors and stem cells have been isolated. Amniotic-derived cells have broad potential, possess immunomodulatory properties, and have been shown to differentiate into cell lineages representing all three embryonic germ layers without generating tumors, which makes them ideal candidates for applications in regenerative medicine. Moreover, their abilities to engraft in injured organs and modulate immune and repair responses of host tissues suggest that transplantation of such cells may be useful for treating various degenerative and inflammatory diseases. Amniotic cells could be banked early in gestation or at term during birth, and evidence supports their potential role as a valuable stem cell source for the field of regenerative medicine.
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